It has a role as an antimicrobial food preservative, a drug allergen, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an algal metabolite, a human xenobiotic metabolite and a plant metabolite. At low pH levels in water, sodium benzoate converts to benzoic acid , the active form of the compound. Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies. Sodium benzoate is the inactive salt of benzoic acid which is soluble in water. The usefulness of sodium benzoate as a preservative is limited by its effectiveness over a narrow pH range. When benzoic acid (80 mg/kg body weight) and sodium bisulfate (160 mg/kg body weight) or their mixture (benzoic acid/sodim bisulfate = 80 mg/160 mg) were fed to mice for 10 weeks, the death rate was 66% from the mixture and 32% from benzoic acid alone. Sodium benzoate is a substance which has the chemical formula C 6 H 5 COONa. The melting point of benzoic acid solid is about 122.41 °C. Furthermore, both these compounds appear as white crystalline solids, but benzoic acid appears as needle-like structures while sodium benzoate is often a powdered solid. As to why, sodium benzoate is the sodium salt of benzoic acid, and it has an ionic bond between the sodium ion and the organic acid group: (COO-)(+Na). It is a widely used food preservative, with an E number of E211.It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid. So, this is another difference between benzoic acid and sodium benzoate. Display Name: Sodium benzoate EC Number: 208-534-8 EC Name: Sodium benzoate CAS Number: 532-32-1 Molecular formula: C7H6O2.Na IUPAC Name: sodium benzoate Sodium benzoate is soluble in water because it dissolves in water very well, to the extent of 60 or so g per 100 g of water depending on the temperature. Sodium salts are usually very soluble in water; but if you have strong acid present or enough strong acid, you may sufficiently convert the sodium benzoate to its acid form (benzoic acid), and for this solubility, check a handbook. Sigma-Aldrich offers a number of Sodium benzoate products. Sodium benzoate is soluble in water because it dissolves in water very well, to the extent of 60 or so g per 100 g of water depending on the temperature. It is used in concentrations of 0.02–0.5% in oral medicines, 0.5% in parenteral products, and 0.1–0.5% in cosmetics. Sodium Benzoate, expressed as benzoic acid, is permitted in oral medicines up to 0.5%, in parenterally administered up to 0.5%. Both these compounds are …

Sodium benzoate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. But for sodium benzoate, the melting point is a very high value – 410 °C. Sodium benzoate is soluble in water because it dissolves in water very well, to the extent of 60 or so g per 100 g of water depending on the temperature. View information & documentation regarding Sodium benzoate, including CAS, MSDS & more. The activity of benzoic acid is very pH dependent, showing low activity above pH 6 and most active at pH3. It is because the ionic bond between the sodium and the benzoic acid breaks in water , leading to dissociation. Ref. Sodium benzoate is used primarily as an antimicrobial preservative in cosmetics, foods, and pharmaceuticals. : AR 4, AR 5 Benzoic acid is also an intermediate in the synthesis of phenol and caprolactam.



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